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November 14, 2016


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Trish Davis

Behan, W.M.H., More, I.A.R. & Behan, P.O. Acta Neuropathol (1991) 83: 61. doi:10.1007/BF00

We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed branching and fusion of mitochondrial cristae. Mitochondrial degeneration was obvious in 40 of the biopsies with swelling, vacuolation, myelin figures and secondary lysosomes. These abnormalities were in obvious contrast to control biopsies, where even mild changes were rarely detected. The findings described here provide the first evidence that PFS may be due to a mitochondrial disorder precipitated by a virus infection.
NOTE: This paper was published in 1991. Simon Wessley must have seen it since he decided around that time to be an ME 'expert'. It demolishes the biopsychosocial theory. I rest my case.

Nasim Marie Jafry

Re. Trish Davis comment, I was actually diagnosed with ME by Behan in early 1984 (please see my previous comment) - I was very ill with Coxsackie virus in late 1982 and continued to become more and more ill - I eventually had EMG and muscle biopsy to confirm the diagnosis of ME. It still stuns me that Wessely has tried to rewrite the narrative of classic ME - an illness he is spectacularly ignorant about. And his oftquoted ' we have to agree to disagree' wholly demonstrates his lack of awareness of the harm his views have caused, as if there has been no consequence whatsoever from his own beliefs.

Dr Paul

There's an anecdote afoot in Britain that when someone with ME asked a Wesselyan or someone influenced by the Wesselyans why her condition had not improved via their prescribed treatments, she was told that it was because she didn't want to get better.

Now, I do not know whether this story is true or false or one of those 'ben trovato' tales that are essentially true even if they didn't actually happen, but nothing would surprise me if it was true.

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